From the Research
Nitrofurantoin is recommended as a first-line treatment for uncomplicated lower urinary tract infections (UTIs) in males, due to its high efficacy and low resistance rates, as supported by recent studies 1, 2. The dosage of nitrofurantoin for males is typically 100 mg taken orally every 12 hours for 7 days, which is longer than the standard 5-day course often used for women, as male UTIs generally require extended treatment due to anatomical differences and potential prostate involvement. Some key points to consider when prescribing nitrofurantoin include:
- Taking the medication with food to improve absorption and reduce gastrointestinal side effects such as nausea or upset stomach
- Completing the entire course of antibiotics even if symptoms improve before finishing the medication
- Maintaining adequate hydration while taking nitrofurantoin
- Avoiding use in patients with significant renal impairment (creatinine clearance <30 mL/min) or suspected pyelonephritis (kidney infection)
- Monitoring for side effects, which are generally mild and include gastrointestinal and central nervous system symptoms, as reported in studies 2. It's essential to note that while nitrofurantoin is effective against most common UTI pathogens, including E. coli, its use should be guided by local resistance patterns and patient-specific factors, as highlighted in studies 3, 4. Overall, the current evidence supports the use of nitrofurantoin as a first-line treatment for uncomplicated UTIs in males, with consideration of individual patient factors and potential side effects 1, 2.