From the Research
The recommended treatment for Aerococcus sanguinicola urinary tract infection is nitrofurantoin, achieving clinical and microbiological success in 42/50% of cases, as shown in a prospective observational study 1.
Treatment Options
- Nitrofurantoin is a valid option for the treatment of cystitis caused by A. sanguinicola, with a success rate of 42/50% 1.
- Alternative treatments include penicillin, ampicillin, or amoxicillin, which are effective against A. sanguinicola, but their success rates are not as well-documented as nitrofurantoin 2, 3.
- Fluoroquinolones like ciprofloxacin may also be effective, but are generally reserved as second-line options due to resistance concerns 4, 5.
Important Considerations
- Aerococcus sanguinicola is a gram-positive coccus that typically responds well to beta-lactam antibiotics because they target cell wall synthesis in these bacteria.
- It's essential to complete the full course of antibiotics even if symptoms improve before completion.
- Increased fluid intake helps flush bacteria from the urinary tract, and urinary analgesics like phenazopyridine may help relieve pain and discomfort while the antibiotics take effect.
- Follow-up urine cultures may be necessary to confirm eradication, especially in complicated cases.
Recent Study Findings
- A 2023 study found that nitroxoline has low activity against A. sanguinicola, with high MICs (MIC50/90 64/128 mg/L) 4.
- The same study showed that A. sanguinicola isolates are susceptible to benzylpenicillin, ampicillin, meropenem, rifampicin, nitrofurantoin, and vancomycin, with 100% susceptibility to these antibiotics 4.