From the Research
Sermorelin is stable and effective at temperatures up to 77°F (25°C) for a short period, but it should be stored refrigerated at 36-46°F (2-8°C) before reconstitution to maintain its potency and shelf life. When considering the storage and administration guidelines for Sermorelin, a Growth Hormone-Releasing Hormone (GHRH) analogue, it's crucial to prioritize the stability and effectiveness of the compound to ensure optimal therapeutic outcomes. The available evidence does not specifically address the temperature stability of Sermorelin in detail, but general guidelines for peptides suggest that they should be stored under refrigeration to maintain their stability and effectiveness 1.
Storage Guidelines
- Sermorelin should be stored refrigerated at 36-46°F (2-8°C) before reconstitution.
- Once reconstituted, the solution should remain refrigerated and protected from light.
- It is recommended to use the reconstituted solution within 30 days after mixing with bacteriostatic water.
Administration Guidelines
- Administration is typically done via subcutaneous injection, using a small insulin syringe (29-31 gauge) into the abdomen.
- Rotating injection sites is crucial to prevent tissue damage.
- The standard dosage ranges from 100-500 mcg per day, usually administered before bedtime to align with the body's natural growth hormone pulse.
- Prior to injection, clean the injection site with an alcohol swab and allow it to dry completely.
- After reconstitution, the solution should appear clear without particles; discard if cloudy or discolored.
Mechanism and Side Effects
- Sermorelin works by stimulating the pituitary gland to produce natural growth hormone, making timing important as growth hormone release is highest during early sleep phases.
- Side effects are generally mild but may include injection site reactions, headache, or flushing.
- Patients should be advised that results typically take several weeks to become noticeable.
Given the information available and the focus on maintaining the stability and effectiveness of Sermorelin, the most critical aspect is storing it under refrigeration before reconstitution and using it within the recommended timeframe after reconstitution. While the exact temperature stability of Sermorelin is not detailed in the provided studies, following standard peptide storage guidelines is prudent to ensure its potency and shelf life 2.