From the Guidelines
Polyethylene glycol (Miralax) is safe to use during pregnancy, as recommended by the most recent clinical practice update on pregnancy-related gastrointestinal and liver disease 1. The use of polyethylene glycol–based laxatives, such as Miralax, is supported by the latest evidence as a treatment option for constipation in pregnant persons, which may result from hormonal, medication-related, and physiological changes 1. Some key points to consider when using Miralax during pregnancy include:
- The typical dose is 17 grams of powder dissolved in 4-8 ounces of water, taken once daily
- It can be used for short-term relief or longer periods if needed under a doctor's guidance
- Miralax works by drawing water into the colon, softening stools and making them easier to pass, without being absorbed into the bloodstream, thus not directly affecting the developing fetus 1
- Other safe options for managing constipation during pregnancy include increasing fiber intake, staying hydrated, and regular exercise when possible
- If constipation persists or worsens despite using Miralax, or if severe abdominal pain or bleeding occurs, it is essential to contact a healthcare provider immediately for further evaluation and guidance. It is crucial for pregnant women to consult their healthcare provider before starting any new medication, including Miralax, to ensure the best possible outcome for both the mother and the fetus 1.
From the FDA Drug Label
IF PREGNANT OR BREAST-FEEDING, ask a health professional before use. The FDA drug label does not provide a direct answer to the question of whether polyethylene glycol (Miralax) is safe during pregnancy, as it advises consulting a health professional before use 2.
From the Research
Safety of Polyethylene Glycol (Miralax) During Pregnancy
- There are no direct studies provided that assess the safety of polyethylene glycol (Miralax) during pregnancy.
- However, studies on other medications and substances during pregnancy can provide some general insights:
- A study on over-the-counter medications during pregnancy 3 discusses the safety of various medications but does not specifically mention polyethylene glycol.
- Another study on biologic agents during pregnancy 4 categorizes the safety of different biologic agents but does not address polyethylene glycol.
- Guidelines for medical imaging during pregnancy and lactation 5 focus on the use of contrast agents and imaging techniques, not on medications like polyethylene glycol.
- A review on the use of medications for Crohn's disease and ulcerative colitis during pregnancy and breastfeeding 6 discusses the safety of various medications for these conditions but does not mention polyethylene glycol.
- Given the lack of direct evidence, it is essential to consult healthcare professionals for guidance on the safe use of polyethylene glycol (Miralax) during pregnancy, as they can provide personalized advice based on the latest research and clinical guidelines 3, 4, 5, 6.