Differential Diagnosis for Intussusception of Small Bowel due to Intestinal Polyps

• Single most likely diagnosis:
  • d. FAP (Familial Adenomatous Polyposis): This condition is characterized by the development of hundreds to thousands of polyps in the colon and rectum, and it can also affect the small intestine. The presence of intestinal polyps leading to intussusception, especially in a middle-aged individual, makes FAP a strong consideration due to its potential for causing such complications through the formation of numerous adenomatous polyps.
• Other Likely diagnoses:
  • a. Juvenile: Juvenile polyps can cause intussusception, especially in the context of juvenile polyposis syndrome, which is a rare condition. While less common than FAP in adults, it remains a possibility, particularly if the polyps are large and numerous enough to lead to intussusception.
  • c. Lipoma: Lipomas are benign tumors made of fat tissue and can occur in the small intestine. They are a known cause of intussusception, especially if they are large enough to act as a lead point. However, they are less commonly associated with a history of multiple intestinal polyps compared to FAP.
• Do Not Miss diagnoses:
  • b. Cowden S (Cowden Syndrome): Although less likely, Cowden syndrome is a genetic disorder characterized by multiple hamartomatous polyps throughout the gastrointestinal tract, among other features. It's crucial not to miss this diagnosis due to its association with increased risk of various cancers. However, it is less commonly associated with intussusception compared to other conditions like FAP.
• Rare diagnoses:
  • Other rare syndromes and conditions that could potentially lead to intestinal polyps and intussusception, such as Peutz-Jeghers syndrome or Cronkhite-Canada syndrome, are less likely but should be considered if the more common diagnoses are ruled out. These conditions often have distinctive clinical features that can help in their identification.