What dose of Crestor (rosuvastatin) is equivalent to 40 milligrams of pravastatin?

There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.

The FDA Drug Labels for pravastatin (PO), rosuvastatin (PO) do not address this question.

From the Research

Equivalent Dose of Crestor (Rosuvastatin) to 40 Milligrams of Pravastatin

• The provided studies do not directly compare the dose of 40 milligrams of pravastatin to a specific dose of rosuvastatin.
• However, the studies suggest that rosuvastatin is more effective than pravastatin in reducing low-density lipoprotein cholesterol (LDL-C) levels 1, 2, 3, 4, 5.
• A study comparing the efficacy of rosuvastatin, atorvastatin, and pravastatin found that rosuvastatin 10 mg reduced LDL-C by 29.03%, while pravastatin 20 mg reduced LDL-C by 20.3% 4.
• Another study found that rosuvastatin 10 mg reduced LDL-C by 42%, while pravastatin 20 mg reduced LDL-C by 28% 1.
• Based on these findings, it can be estimated that a dose of rosuvastatin that is equivalent to 40 milligrams of pravastatin may be around 10-20 mg of rosuvastatin, but this is not a direct comparison and the actual equivalent dose may vary.

LDL-C Reduction Comparison

• Rosuvastatin 10 mg: 42% reduction in LDL-C 1
• Rosuvastatin 10 mg: 29.03% reduction in LDL-C 4
• Pravastatin 20 mg: 28% reduction in LDL-C 1
• Pravastatin 20 mg: 20.3% reduction in LDL-C 4
• Pravastatin 40 mg: no direct comparison available in the provided studies

Safety Profile

• All the studies found that rosuvastatin and pravastatin have similar safety profiles, with no significant differences in adverse events 1, 2, 3, 4, 5.
• Rosuvastatin 10-40 mg demonstrated a similar adverse event profile to atorvastatin 10-80 mg, simvastatin 10-80 mg, and pravastatin 10-40 mg 5.