From the Research
Fluconazole is typically not the first-line treatment for intertrigo, and when used, the typical regimen is 150-200 mg taken once daily for 7-14 days. For intertrigo with fungal involvement (candidal intertrigo), topical antifungal treatments are generally preferred over oral fluconazole 1. However, when oral fluconazole is indicated for severe or resistant cases, treatment should be accompanied by keeping the affected areas clean and dry, as moisture exacerbates intertrigo. Patients should gently wash the area with mild soap, thoroughly dry it, and apply prescribed topical treatments before considering oral therapy. Some key points to consider when treating intertrigo with fluconazole include:
- The importance of maintaining good hygiene and keeping the affected area dry to prevent moisture from exacerbating the condition
- The use of topical antifungal treatments as the first line of treatment, reserving oral fluconazole for severe or resistant cases
- The potential for fluconazole to interact with other medications, and the need for careful monitoring in patients with certain medical conditions
- The role of fluconazole in inhibiting fungal cytochrome P450 enzymes, preventing the synthesis of ergosterol, and ultimately leading to fungal cell death 2. It's also worth noting that while fluconazole can be effective in treating intertrigo, it's not always the best choice, and other treatments such as itraconazole may be more suitable in certain cases 3. In terms of dosing, a study from 1992 found that once-weekly oral doses of fluconazole 150 mg were effective in treating tinea corporis and cutaneous candidiasis 2. However, more recent studies have not specifically addressed the use of fluconazole in intertrigo, and the current recommendation is based on clinical experience and expert opinion. Overall, while fluconazole can be a useful treatment for intertrigo, it's essential to carefully consider the individual patient's needs and circumstances before initiating treatment.