From the FDA Drug Label
ADVERSE REACTIONS Adverse reactions reported coincident with the administration of methocarbamol include: ... Cardiovascular system: ... hypotension, ... OVERDOSAGE ... Overdose of methocarbamol ... includes the following symptoms: ... hypotension, ...
Yes, Robaxin (methocarbamol) can cause hypotension 1 1.
- Hypotension is listed as a possible adverse reaction in the drug label 1.
- Hypotension is also a symptom of overdose 1.
From the Research
Yes, Robaxin (methocarbamol) can cause hypotension as a side effect, particularly when administered intravenously or in high doses. This muscle relaxant works by depressing the central nervous system and may lead to a drop in blood pressure, especially in patients with cardiovascular conditions or those taking other medications that lower blood pressure. The risk is higher with IV administration compared to oral tablets.
Key Considerations
- Patients should be monitored for symptoms of hypotension such as dizziness, lightheadedness, or fainting, particularly when starting treatment or increasing the dose.
- Those with a history of cardiovascular disease, elderly patients, and individuals taking antihypertensives should use Robaxin with caution.
- The hypotensive effect occurs because methocarbamol can cause peripheral vasodilation and decrease peripheral vascular resistance, which leads to reduced blood pressure.
- If hypotension develops, patients should be advised to sit or lie down, stay hydrated, and contact their healthcare provider if symptoms are severe or persistent.
Evidence Summary
According to a recent study 2, certain medications, including muscle relaxants like methocarbamol, can cause hypotension. Another study 3 found that medications prescribed for common conditions, including those that cause sympathetic inhibition, were associated with significantly increased odds of orthostatic hypotension. However, the most relevant study to this question is 4, which demonstrated the efficacy and safety of methocarbamol in treating acute low back pain, but did not specifically address hypotension as a side effect.
Clinical Implications
Given the potential for hypotension, particularly in vulnerable populations, it is essential to weigh the benefits and risks of using Robaxin in these patients. Healthcare providers should closely monitor patients for signs of hypotension and adjust treatment accordingly. The use of Robaxin should be approached with caution in patients with a history of cardiovascular disease, elderly patients, and those taking antihypertensive medications.