From the FDA Drug Label
DOSAGE AND ADMINISTRATION Take orally with or without food, at any time of day. The optimal time of day to take Crestor (Rosuvastatin) is any time of day, as it can be taken with or without food. 1
From the Research
Crestor (rosuvastatin) is best taken in the evening, typically before bedtime, as this timing aligns with the body's natural peak in cholesterol production and may lead to slightly better cholesterol-lowering effects compared to morning dosing. For optimal effectiveness, it's recommended to take Crestor consistently at the same time each day, with or without food, at the prescribed dose. The reasoning behind evening dosing includes:
- Cholesterol production in the liver is highest at night, as noted in a review of current evidence on the optimal time of day for statin administration 2.
- The medication's half-life is long enough to work throughout the night when taken in the evening, which is beneficial for maintaining consistent cholesterol-lowering effects.
- Evening dosing may lead to slightly better cholesterol-lowering effects compared to morning dosing, although the difference may not be significant for all patients.
If you have trouble remembering to take it at night, taking it in the morning is still beneficial and better than missing doses. Always follow your doctor's specific instructions, as they may have reasons for recommending a different time based on your individual needs or other medications you're taking. It's also important to consider that the current evidence is based on a review of available clinical studies and meta-analyses, and larger, more recent studies may provide further guidance on the optimal timing of statin administration 2.