What is the recommended dosage of Tadalafil (Cialis) for erectile dysfunction and benign prostatic hyperplasia (BPH)?

From the Guidelines

For erectile dysfunction, the recommended dosage of Tadalafil (Cialis) is typically 10 mg taken orally before anticipated sexual activity, with a maximum of one dose per day, as supported by high-quality evidence from studies such as 1 and 1. This can be adjusted to 5 mg if effective or increased to 20 mg if needed. Alternatively, a daily dosing regimen of 2.5 to 5 mg can be used regardless of timing of sexual activity. For benign prostatic hyperplasia (BPH), the recommended dosage is 5 mg taken once daily at approximately the same time. Tadalafil works by inhibiting phosphodiesterase type 5 (PDE5), which increases blood flow to the penis for erectile dysfunction and relaxes smooth muscle in the prostate and bladder for BPH symptoms. The medication can be taken with or without food, but alcohol should be limited as it may increase the risk of dizziness or low blood pressure. Patients with severe kidney or liver impairment may require dose adjustments, typically starting at the lower 5 mg dose. Common side effects include headache, indigestion, back pain, muscle aches, flushing, and nasal congestion.

Some key points to consider when prescribing Tadalafil include:

• The medication is effective for a wide range of patients, including those with specific medical conditions such as diabetes, depression, and cardiovascular disease, as shown in studies like 1 and 1.
• Tadalafil has been compared to other PDE-5 inhibitors, such as sildenafil, and has been found to have similar efficacy, as reported in studies like 1 and 1.
• The medication can be used in combination with other ED therapies, such as psychotherapy and hormonal treatments, to improve erectile function and frequency of penile penetration or maintenance of erection, as discussed in studies like 1 and 1.
• Tadalafil has also been studied for its use in treating pulmonary hypertension, and has been found to have favorable results, as reported in studies like 1 and 1.

From the FDA Drug Label

The recommended starting dose of tadalafil tablets for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The recommended starting dose of tadalafil tablets for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The tadalafil tablets dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability. The recommended dose of tadalafil tablets for once daily use for Benign Prostatic Hyperplasia is 5 mg, taken at approximately the same time every day. The recommended dose of tadalafil tablets for once daily use for Erectile Dysfunction and Benign Prostatic Hyperplasia is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.

The recommended dosage of Tadalafil (Cialis) for erectile dysfunction is:

• 10 mg taken prior to anticipated sexual activity, for use as needed
• 2.5 mg to 5 mg taken at approximately the same time every day, for once daily use

The recommended dosage of Tadalafil (Cialis) for benign prostatic hyperplasia (BPH) is:

• 5 mg taken at approximately the same time every day, for once daily use

The recommended dosage of Tadalafil (Cialis) for erectile dysfunction and BPH is:

• 5 mg taken at approximately the same time every day, for once daily use 2

From the Research

Tadalafil Dosage for Erectile Dysfunction and Benign Prostatic Hyperplasia (BPH)

• The recommended dosage of Tadalafil (Cialis) for erectile dysfunction is 5mg or 10mg once daily, as shown in a multicenter, randomized, double-blind, placebo-controlled trial 3.
• For benign prostatic hyperplasia (BPH), the recommended dosage is 5mg once daily, which has been shown to be effective in treating the signs and symptoms of BPH, including improvements in the total International Prostate Symptom Score (IPSS) 4, 5.
• Tadalafil 5mg once daily has also been shown to be effective in treating both erectile dysfunction and BPH in men with both conditions, with significant improvements in the International Index of Erectile Function-Erectile Function domain score and the total IPSS 4.

Efficacy and Safety of Tadalafil

• Tadalafil has been shown to be well tolerated and effective in treating erectile dysfunction, with significant improvements in erectile function and treatment satisfaction 3, 6.
• The safety profile of tadalafil is well established, with no new or unexpected adverse events reported in studies of up to 1 year in duration 4, 5.
• Common adverse events associated with tadalafil include dyspepsia, headache, back pain, upper abdominal pain, and myalgia, which are generally mild to moderate in intensity 3.

Comparison with Other Phosphodiesterase Type-5 Inhibitors

• Tadalafil has been compared with other phosphodiesterase type-5 inhibitors, such as sildenafil and vardenafil, and has been shown to have similar efficacy and safety profiles 7.
• However, tadalafil has a longer half-life than sildenafil and vardenafil, which may make it more suitable for once-daily dosing 3, 7.