From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The recommended dose of ganaxolone for a child weighing 20 kg is 1260 mg per day, with a maximum dose of 63 mg/kg per day. To administer:
- Give the dose in divided amounts, three times daily
- Use the oral suspension formulation
- Administer with food to improve absorption Start at a lower dose and increase to the full dose if tolerated. Monitor for side effects such as drowsiness or dizziness. This dosing is based on the study by 1, which used a maximum dose of 63 mg/kg per day for patients weighing ≤28 kg. The 1260 mg daily dose for a 20 kg child falls within this range at 63 mg/kg/day. Ganaxolone works as a neurosteroid that enhances GABA-mediated inhibition in the brain, helping to reduce seizure activity in certain epilepsy syndromes. Some key points to consider:
- The study by 1 is the most recent and highest quality study, and its findings should be prioritized.
- The dosing regimen should be individualized based on the child's response to the medication and tolerance of side effects.
- Close monitoring of the child's condition and adjustment of the dose as needed is crucial to ensure optimal treatment outcomes.