From the Research
The most effective skin substitute for a head and neck excision is Integra, as it provides a safe and viable alternative for both partial and full thickness scalp defects, reducing complications and the need for additional procedures, with a high success rate of 95% as reported in the most recent study 1. When considering skin substitutes for head and neck excisions, several factors come into play, including the size and depth of the defect, the location, exposure to critical structures, patient comorbidities, and desired cosmetic outcomes.
- Acellular dermal matrices (ADMs) like Integra are often preferred due to their ability to provide an effective scaffold for tissue regeneration while maintaining structural integrity in the aesthetically important head and neck region.
- For smaller defects, split-thickness skin grafts may be sufficient, but for larger or more complex defects, local or regional flaps or free tissue transfers may be necessary.
- The use of Integra has been supported by multiple studies, including a systematic review that found it to be effective in reconstructing large scalp wounds with a high percent graft take and minimal complications 2.
- Additionally, a study published in 2023 discussed the design and clinical use of Integra, highlighting its mechanism of action and its potential benefits in wound healing 3.
- Another study from 2019 provided recommendations from a multidisciplinary advisory board on the use of Integra in scalp reconstruction after tumor excision, emphasizing its value in elderly patients with multiple comorbidities and in the reconstruction of large and complex wounds 4.
- Overall, the choice of skin substitute should be tailored to the individual patient's needs, taking into account the specific clinical situation and the potential benefits and drawbacks of each option, with Integra being a highly recommended choice due to its high success rate and minimal complications as reported in the most recent study 1.