From the Research
The recommended dose of aspirin for migraine treatment is 900-1300 mg at the onset of migraine symptoms, as suggested by the most recent and highest quality study 1. This dose may be repeated every 4-6 hours if needed, not exceeding 4000 mg per day. For many patients, this high dose of aspirin can effectively reduce migraine pain by inhibiting the enzyme cyclooxygenase, which decreases the production of prostaglandins and thromboxanes that contribute to inflammation and pain. Some key points to consider when using aspirin for migraine treatment include:
- Taking aspirin with a small amount of food or liquid may help reduce stomach irritation, which is a common side effect.
- Some patients find that combining aspirin with caffeine (around 65-130 mg) enhances its effectiveness, as caffeine can improve absorption and may have additional pain-relieving properties.
- However, aspirin should be used cautiously in those with a history of stomach ulcers, bleeding disorders, or aspirin sensitivity, and should be avoided in children under 16 due to the risk of Reye's syndrome.
- If migraines are frequent or severe, consultation with a healthcare provider is recommended to discuss preventive treatments rather than relying solely on aspirin for symptom management, as supported by other studies 2, 3, 4, 5.