From the FDA Drug Label
Adults: The usual dose is one 5-mg tablet two to three times a day. The maximum recommended dose is one 5-mg tablet four times a day. The recommended dose and frequency of oxybutynin for adults is:
- Usual dose: 5 mg, two to three times a day
- Maximum dose: 5 mg, four times a day 1
From the Research
The recommended dose of oxybutynin for adults is typically 5-10 mg taken orally once daily, with a maximum daily dose of 30 mg, as an extended-release formulation, due to its smoother plasma concentration-time profile and lower maximum plasma concentration compared to immediate-release formulations 2. When considering the treatment of overactive bladder, it's essential to weigh the benefits and risks of oxybutynin against other available options, such as beta-3 agonists, which may have a lower risk of dementia 3, 4.
- The dose and frequency of oxybutynin may need to be adjusted based on individual response and tolerability.
- Oxybutynin is also available as a transdermal patch (3.9 mg/day) applied twice weekly, and as a topical gel (10% gel, 1 gram) applied once daily.
- Elderly patients may require lower doses due to increased sensitivity to anticholinergic effects.
- Combination therapy with mirabegron, a beta-3 agonist, may be considered for patients with moderate-to-severe symptoms, as it has been shown to be effective and well-tolerated 5.
- However, the risk of dementia associated with anticholinergic use, including oxybutynin, should be carefully considered, especially in patients with risk factors for dementia 3, 4.
- Persistence and adherence with oxybutynin may be lower compared to mirabegron, which has been shown to have a longer time-to-discontinuation and higher adherence rates 6.