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Differential Diagnosis for Hives in Pregnancy

Single Most Likely Diagnosis

  • Urticaria of pregnancy: This is the most common cause of hives in pregnancy, accounting for approximately 70% of cases. It is thought to be related to the hormonal changes and immune system modulation that occur during pregnancy.

Other Likely Diagnoses

  • Allergic reactions: Allergic reactions to foods, medications, or environmental factors can cause hives in pregnancy, just as they can in the non-pregnant population.
  • Infections: Infections such as urinary tract infections, respiratory tract infections, or skin infections can trigger hives in pregnant women.
  • Autoimmune disorders: Conditions like thyroid disease or lupus can cause hives in pregnancy, although these are less common.

Do Not Miss Diagnoses

  • Preeclampsia: Although rare, preeclampsia can present with hives, and it is a potentially life-threatening condition for both the mother and the fetus if not promptly recognized and treated.
  • HELLP syndrome: A variant of preeclampsia, HELLP syndrome (Hemolysis, Elevated Liver enzymes, and Low Platelet count) can also present with hives and requires immediate medical attention.
  • Anaphylaxis: A severe, life-threatening allergic reaction that can cause hives, among other symptoms. Prompt recognition and treatment with epinephrine are crucial.

Rare Diagnoses

  • Hereditary angioedema: A rare genetic disorder that can cause recurrent episodes of hives, often without an identifiable allergen or cause.
  • Mastocytosis: A condition characterized by an accumulation of mast cells in the skin, which can cause hives and other symptoms.
  • Cholestasis of pregnancy: A condition that occurs in some pregnant women, characterized by severe itching (pruritus) and can sometimes present with hives, although this is less common.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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