From the Research
No, Elephantiasis nostras verrucosa does not typically cause hypercalcemia. Elephantiasis nostras verrucosa is a chronic lymphedema condition characterized by progressive swelling and skin changes, primarily affecting the lower extremities. It results from chronic lymphatic obstruction due to various causes such as recurrent infections, obesity, or venous insufficiency. The condition leads to fibrosis, hyperkeratosis, and papillomatosis of the skin, giving it a cobblestone or warty appearance. However, this condition affects the lymphatic system and skin, without disrupting calcium metabolism pathways in the body. Hypercalcemia (elevated blood calcium levels) is typically caused by conditions that affect calcium regulation, such as hyperparathyroidism, certain malignancies, granulomatous disorders, or medication effects. The pathophysiology of Elephantiasis nostras verrucosa does not involve these calcium-regulating mechanisms, and therefore it does not lead to hypercalcemia.
Management of Elephantiasis nostras verrucosa focuses on treating the underlying cause, compression therapy, skin care, and sometimes surgical interventions, rather than addressing calcium imbalances. According to a recent case report and literature review 1, the management of ENV is often challenging, but a variety of successful medical and surgical treatment strategies have been reported. Another study 2 also reported a case of elephantiasis nostras verrucosa treated with furosemide and homeopathic Apocynum cannabinum, which showed significant improvement in limb diameter and skin appearance.
The key points to consider in the management of Elephantiasis nostras verrucosa include:
- Treating the underlying cause of the condition
- Compression therapy to reduce swelling
- Skin care to prevent infections and promote healing
- Surgical interventions in severe cases
- Monitoring for potential complications, such as cellulitis or abscesses. As noted in a review of the condition 3, Elephantiasis nostras verrucosa is a progressive condition, and without intervention, ongoing deformity and disability will result. Therefore, early diagnosis and treatment are crucial to prevent long-term complications and improve quality of life.