What is the brand name of pramipexole?

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Brand Name of Pramipexole

The brand name of pramipexole is Mirapex (or Mirapex ER for the extended-release formulation). 1

Brand Name Details

Pramipexole was first manufactured by Pharmacia and Upjohn in July 1997 under the United States brand names Mirapex and Mirapex ER 1. The drug is also marketed under the brand name Sifrol in some international markets, particularly by Boehringer Ingelheim 2.

Generic Availability

Generic pramipexole dihydrochloride tablets are now widely available and have been shown to be bioequivalent to the brand-name formulations 2, 3. Studies demonstrate that generic pramipexole has:

  • Comparable efficacy to brand-name formulations in treating Parkinson's disease
  • Similar safety profiles with no significant difference in adverse event occurrence
  • Significantly lower cost while maintaining therapeutic equivalence 3

Clinical Context

Pramipexole is classified as a nonergoline aminobenzothiazole compound and dopamine D2-like receptor agonist with D3-preferring properties 1. It is FDA-approved for:

  • Treatment of signs and symptoms of idiopathic Parkinson's disease 4, 1
  • Moderate to severe symptoms of primary restless legs syndrome 5, 1

The medication is available in both immediate-release and extended-release formulations, with the extended-release version allowing for once-daily dosing 2.

References

1
Research

Classics in Chemical Neuroscience: Pramipexole.

ACS chemical neuroscience, 2020

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