Can Tadalafil (phosphodiesterase type 5 inhibitor) be taken with Trimix (intracavernosal injection)?

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Last updated: June 5, 2025 • View editorial policy

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From the Research

Tadalafil can be taken with Trimix injections, but with careful consideration and monitoring due to the potential increased risk of prolonged erections, as evidenced by a study published in 2023 1. The study found that the incidence of priapism was not significantly different between tadalafil and sildenafil users, but tadalafil patients had a higher rate of prolonged erections, which occurred mostly during the early titration phase. Key points to consider include:

  • The risk of priapism and prolonged erections when combining Tadalafil with Trimix injections
  • The importance of careful monitoring and education on proper injection techniques to minimize the risk of adverse events
  • The need for medical supervision and consideration of individual health conditions and other medications when making decisions about using these medications together
  • The potential for an additive effect that significantly increases the risk of a painful erection lasting more than 4 hours, which is a medical emergency requiring immediate treatment, as noted in other studies 2, 3. However, the most recent and highest quality study 1 suggests that with proper monitoring and precautions, the combination of Tadalafil and Trimix injections can be safe and effective for some patients. It is essential to weigh the potential benefits and risks and to consult with a healthcare provider before making any decisions about using these medications together. Some studies have reported cases of priapism associated with Tadalafil use 2, 3, but the overall incidence remains relatively low. In contrast, other studies have focused on the efficacy and safety of Tadalafil as a monotherapy 4, 5, rather than in combination with Trimix injections. Ultimately, the decision to use Tadalafil with Trimix injections should be made on a case-by-case basis, taking into account individual patient factors and medical history, and under the guidance of a qualified healthcare provider.

Related Questions

I am a 21‑year‑old male with a month‑long partially rigid erection (partial priapism) after taking tadalafil (5 mg daily then 10 mg) and sildenafil (30 mg × 2); how long can I expect it to take for complete resolution and healing?
In an adult male who took daily tadalafil (Cialis) 5 mg for two weeks, then a single 10 mg dose, followed by two 30 mg doses of sildenafil (Viagra) on the same night and now presents with a month‑long persistent partially rigid, discolored penis, numbness, urinary and bowel symptoms, what is the expected healing timeline and is continued penile discoloration normal before full recovery?
What is causing my medication‑induced partially rigid erection (partial priapism) after taking tadalafil (5 mg daily for two weeks then a single 10 mg dose) and sildenafil (two 30 mg doses taken close together), and how should it be managed?
I am a male who took 10 mg tadalafil followed by multiple 30 mg sildenafil doses 28 days ago and now have a persistent partially rigid, dark, firm penile shaft with a soft tip, numbness, discoloration, and new urinary and bowel symptoms. How long can this condition take to fully heal, and what urgent interventions are indicated?
How should a 21‑year‑old male who took 10 mg tadalafil (Cialis) with 60 mg sildenafil and now presents with prolonged erection, persistent rigidity, discoloration, tip numbness, and penile deformity be evaluated and managed?
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