Can Tadalafil (phosphodiesterase type 5 inhibitor) be taken with Trimix (intracavernosal injection)?

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Last updated: June 5, 2025View editorial policy

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From the Research

Tadalafil can be taken with Trimix injections, but with careful consideration and monitoring due to the potential increased risk of prolonged erections, as evidenced by a study published in 2023 1. The study found that the incidence of priapism was not significantly different between tadalafil and sildenafil users, but tadalafil patients had a higher rate of prolonged erections, which occurred mostly during the early titration phase. Key points to consider include:

  • The risk of priapism and prolonged erections when combining Tadalafil with Trimix injections
  • The importance of careful monitoring and education on proper injection techniques to minimize the risk of adverse events
  • The need for medical supervision and consideration of individual health conditions and other medications when making decisions about using these medications together
  • The potential for an additive effect that significantly increases the risk of a painful erection lasting more than 4 hours, which is a medical emergency requiring immediate treatment, as noted in other studies 2, 3. However, the most recent and highest quality study 1 suggests that with proper monitoring and precautions, the combination of Tadalafil and Trimix injections can be safe and effective for some patients. It is essential to weigh the potential benefits and risks and to consult with a healthcare provider before making any decisions about using these medications together. Some studies have reported cases of priapism associated with Tadalafil use 2, 3, but the overall incidence remains relatively low. In contrast, other studies have focused on the efficacy and safety of Tadalafil as a monotherapy 4, 5, rather than in combination with Trimix injections. Ultimately, the decision to use Tadalafil with Trimix injections should be made on a case-by-case basis, taking into account individual patient factors and medical history, and under the guidance of a qualified healthcare provider.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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