From the Research
The caloric content of 500 mL of D5W (5% Dextrose in Water) solution is approximately 85 calories. D5W contains 5 grams of dextrose (glucose) per 100 mL, so a 500 mL bag contains 25 grams of dextrose total. Since each gram of dextrose provides about 3.4 calories, the 25 grams in this solution yields approximately 85 calories. This relatively low caloric content makes D5W primarily useful for hydration while providing minimal nutritional support. The solution is isotonic when administered but becomes hypotonic in the body as the glucose is metabolized, leaving free water. D5W is commonly used in clinical settings to maintain vascular access, deliver medications, treat hypoglycemia, or provide modest free water replacement, but it's essential to note that it doesn't contain electrolytes or significant nutritional value for patients requiring more substantial caloric intake. None of the provided studies 1, 2, 3, 4 directly address the caloric content of D5W solution, but the calculation is based on the known concentration of dextrose in the solution and the caloric value of glucose.