Volume of 400mg Aripiprazole Long-Acting Injectable Vials
Each 400 mg vial of aripiprazole long-acting injectable (AOM) is supplied as a lyophilized powder that requires reconstitution, not as a pre-filled volume. The vial contains aripiprazole monohydrate powder equivalent to 400 mg of aripiprazole that must be reconstituted with sterile water for injection before administration 1, 2.
Key Reconstitution Details
- The 400 mg vial is a lyophilized (freeze-dried) powder formulation, not a liquid solution 2
- After reconstitution with the appropriate volume of sterile water (typically 1.9 mL), the resulting suspension is administered as an intramuscular injection
- The actual injectable volume after reconstitution is approximately 2 mL for the 400 mg dose
Clinical Context
The 400 mg dose is the standard monthly maintenance dose for aripiprazole once-monthly (AOM) long-acting injectable, administered via gluteal or deltoid intramuscular injection every 4 weeks 3, 2. This formulation has an elimination half-life of 29.9-46.5 days, which supports the monthly dosing interval 2.
Important: The vial requires proper reconstitution technique by trained healthcare personnel before administration. The powder must be fully suspended in the diluent to ensure accurate dosing.