Brand Names for Nitrofurantoin Monohydrate
The provided evidence does not contain specific brand name information for nitrofurantoin monohydrate formulations. However, based on the clinical literature and FDA drug labeling provided, I can identify the following:
Available Formulations Referenced
The evidence consistently refers to "nitrofurantoin monohydrate/macrocrystals" as the specific formulation studied in clinical trials 1. This dual-crystal formulation is the one recommended in guidelines for treatment of uncomplicated cystitis at 100 mg twice daily for 5-7 days 1.
The FDA drug label references "nitrofurantoin (macrocrystals)" as a distinct formulation 2, though this appears to be the macrocrystalline form rather than the monohydrate/macrocrystal combination.
Important Clinical Context
While specific brand names are not detailed in the evidence provided, the clinical literature makes clear distinctions between formulations:
- Nitrofurantoin monohydrate/macrocrystals - the preferred formulation for UTI treatment
- Nitrofurantoin macrocrystals - studied separately in some trials 1
- Hydroxymethylnitrofurantoin - prolonged-action formulations with significantly lower bioavailability 3
The bioavailability study demonstrates that different nitrofurantoin formulations are NOT pharmacokinetically equivalent 3. The prolonged-action hydroxymethylnitrofurantoin formulations showed relative bioavailability of only 53-86% compared to macrocrystalline nitrofurantoin, which has important therapeutic implications.
Prescribing Recommendation
When prescribing nitrofurantoin for uncomplicated cystitis, specify "nitrofurantoin monohydrate/macrocrystals 100 mg" rather than relying on brand names, as this ensures the patient receives the formulation with established efficacy in clinical trials 1, 4, 5.