Differential Diagnosis for Anterior Maxilla Lesion

• Single most likely diagnosis
  • Nasopalatine Duct Cyst: This is the most likely diagnosis given the location in the anterior maxilla and the microscopic description of the cyst lining epithelium, which matches the characteristics of a nasopalatine duct cyst.
• Other Likely diagnoses
  • Radicular Cyst: Although less likely given the location and description, a radicular cyst could be considered if the lesion were associated with a non-vital tooth.
  • Dentigerous Cyst: This could be a possibility if the lesion were associated with an unerupted tooth, but the description does not support this.
  • Keratocystic Odontogenic Tumor (KCOT): Now known as Keratocystic Odontogenic Tumor, this lesion has a distinct microscopic appearance that was not described in the provided information.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Squamous Cell Carcinoma: Although the microscopic description mentions nondysplastic stratified squamous epithelium, any lesion in the maxilla with squamous epithelium should prompt consideration of squamous cell carcinoma to rule out malignancy.
  • Ameloblastoma: While rare and not typically found in the anterior maxilla, ameloblastoma is a type of odontogenic tumor that could have significant implications if missed.
• Rare diagnoses
  • Adenomatoid Odontogenic Tumor (AOT): This is a rare tumor that could present in the anterior maxilla but would have distinct microscopic features not described here.
  • Calcifying Epithelial Odontogenic Tumor (CEOT): Another rare odontogenic tumor, CEOT has characteristic microscopic features including amyloid deposits and calcifications, which were not mentioned.
  • Central Giant Cell Granuloma: Although more commonly found in the mandible, this lesion could occur in the maxilla and has a distinct microscopic appearance with giant cells.