From the Guidelines
The maximum recommended dose of ciprofloxacin (Cipro) for adults with normal renal function is 750 mg twice daily, with a maximum daily dose of 1500 mg. This dosage is supported by the British Thoracic Society guideline for bronchiectasis in adults 1, which recommends ciprofloxacin 500 mg or 750 mg twice daily for various infections, including those caused by Coliforms and Pseudomonas aeruginosa.
Key Considerations
- For patients with impaired kidney function, dosing should be adjusted, with reductions to 250-500 mg once daily when creatinine clearance is below 30 ml/min, as suggested by guidelines for preventing opportunistic infections among HIV-infected persons 1.
- Ciprofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and ultimately killing susceptible bacteria.
- The medication should be taken with a full glass of water, either with or without food, though absorption may be reduced if taken with products containing calcium, magnesium, aluminum, iron, or zinc.
Treatment Duration
- Treatment duration varies by infection type, typically ranging from 3-14 days, though complicated infections may require longer courses.
- Patients should complete the full prescribed course even if symptoms improve before finishing the medication.
Important Notes
- It is crucial to follow the recommended dosage and treatment guidelines to ensure effective treatment and minimize the risk of adverse effects.
- Patients with certain medical conditions, such as renal failure, or those taking certain medications, should be closely monitored and may require adjusted dosing.
From the Research
Maximum Dosis of Cipro
The maximum recommended dose of ciprofloxacin (Cipro) varies depending on the patient's condition and the causative pathogen.
- For patients with infections caused by pathogens with a minimum inhibitory concentration (MIC) ≤ 0.125 mg/L and an estimated glomerular filtration rate (eGFR) < 130 mL/min, a dose of 400 mg every 12 hours may be sufficient 2.
- However, for patients with infections caused by pathogens with an MIC ≥ 0.5 mg/L and an eGFR > 100 mL/min, doses up to 600 mg four times daily or more may be required 2.
- In some studies, ciprofloxacin was administered at a dosage of 750 mg twice daily 3, 4 or 1.5-2.25 g/day 5, 6 for the treatment of malignant external otitis.
- The maximum dose of ciprofloxacin used in these studies was 1.5-2.25 g/day 5 or 750 mg twice daily 3, 4.