Generic Name of Loprox
The generic name of Loprox is ciclopirox 1.
Medication Overview
Ciclopirox is a broad-spectrum antifungal agent available in multiple formulations under the brand name Loprox. The medication comes as:
- Topical solution 8% (Nail Lacquer) - for fungal nail infections (onychomycosis)
- Gel 0.77% - for superficial fungal infections
- Cream formulations - for various dermatologic fungal conditions
Mechanism and Indications
Ciclopirox is a hydroxypyridone antifungal with a unique mechanism of action involving high affinity for trivalent cations, which inhibits essential enzyme co-factors 2. Beyond its antifungal properties, it also demonstrates antibacterial and anti-inflammatory effects 2, 3.
FDA-approved indications include:
- Tinea pedis (athlete's foot)
- Tinea corporis (ringworm)
- Pityriasis versicolor
- Seborrheic dermatitis
- Cutaneous candidiasis
- Onychomycosis (nail lacquer formulation)
Clinical Efficacy
The medication has demonstrated effectiveness particularly in seborrheic dermatitis of the scalp, where 1% ciclopirox shampoo achieved a 62% reduction in Total Dandruff Severity Score over 12 weeks 4. For nail infections, the 8% topical solution penetrates up to approximately 0.4 mm depth in nail plates 1.
Safety Profile
Ciclopirox is generally well tolerated with minimal systemic absorption. Common adverse effects include mild burning sensation (13% of users), contact dermatitis, and pruritus 2, 3. Systemic absorption after topical application is less than 5% of the applied dose 1.