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Last updated: June 6, 2025View editorial policy

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Differential Diagnosis for a 3-month-old with Excessive Gas

  • Single most likely diagnosis
    • Functional gastrointestinal disorder (e.g., infantile gas, colic): This is the most common cause of excessive gas in infants, often due to swallowing air during feeding or an immature digestive system.
  • Other Likely diagnoses
    • Lactose intolerance: Some infants may have difficulty digesting lactose, leading to gas and discomfort.
    • Formula intolerance: Similar to lactose intolerance, some infants may react to certain formulas, causing gas and other symptoms.
    • Overfeeding or improper feeding technique: Feeding too much or too quickly can lead to swallowing air and excessive gas.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Intestinal obstruction: Although rare, conditions like pyloric stenosis, intussusception, or volvulus can cause severe vomiting, abdominal distension, and gas.
    • Hirschsprung's disease: A congenital condition characterized by the absence of nerve cells in the colon, leading to severe constipation, gas, and potentially life-threatening complications.
    • Gastroesophageal reflux disease (GERD): While not typically fatal, untreated GERD can lead to significant morbidity, including feeding difficulties, failure to thrive, and respiratory complications.
  • Rare diagnoses
    • Congenital sucrose-isomaltase deficiency: A rare genetic disorder affecting carbohydrate digestion, leading to gas, bloating, and diarrhea.
    • Fructose malabsorption: Some infants may have difficulty absorbing fructose, resulting in gas, bloating, and other gastrointestinal symptoms.
    • Small intestine bacterial overgrowth (SIBO): Although more common in older children and adults, SIBO can occur in infants, particularly those with underlying medical conditions or anatomical abnormalities.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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