From the Research
Tirosint is a brand name for levothyroxine sodium, a synthetic form of the thyroid hormone thyroxine (T4) used to treat hypothyroidism, with a unique liquid formulation that offers consistent absorption and fewer inactive ingredients, making it beneficial for patients with allergies or absorption issues.
Key Characteristics of Tirosint
- It comes in a liquid-filled gel capsule formulation, which contains fewer inactive ingredients than other levothyroxine tablets.
- Tirosint is typically taken once daily on an empty stomach, at least 30-60 minutes before eating.
- Dosing is individualized based on lab results and patient symptoms, usually starting at lower doses (25-50 mcg) and gradually increasing as needed.
- The medication works by replacing the natural thyroid hormone that the body is unable to produce in sufficient quantities, helping to regulate metabolism and energy production throughout the body.
Clinical Utility and Benefits
- According to a study published in 2020 1, liquid LT4, such as Tirosint, is more effective than tablet formulation in patients with malabsorption caused by interfering diseases, drugs, and bariatric surgery.
- The same study found that liquid LT4 has better pharmacokinetics in subjects without malabsorption, resulting in better hormonal control and less frequent TSH measurements.
- A more recent study from 2024 2 demonstrated that the bioavailability of Tirosint-SOL, a novel liquid formulation of levothyroxine, is not affected by coadministration of a proton pump inhibitor (PPI), making it a suitable option for patients on PPI therapy.
Patient Considerations
- Tirosint may be particularly helpful for patients with gastrointestinal conditions like celiac disease, lactose intolerance, or those taking medications that might interfere with levothyroxine absorption.
- The lack of alcohol content in the new formulation, Tirosint SOL, makes it an attractive option for patients who need to avoid alcohol.
- As with any medication, it is essential to follow the prescribed dosage and administration instructions to ensure optimal efficacy and safety.