CHA₂DS₂-VA Score Components
The CHA₂DS₂-VA score consists of seven components that assess thromboembolic risk in atrial fibrillation, notably excluding female sex from the traditional CHA₂DS₂-VASc score. 1
Score Components and Point Values
The 2024 ESC Guidelines provide the definitive breakdown of the CHA₂DS₂-VA scoring system 1:
C - Chronic Heart Failure (1 point)
- Symptoms and signs of heart failure regardless of left ventricular ejection fraction (LVEF)
- Includes HFpEF, HFmrEF, and HFrEF
- Also includes asymptomatic LVEF ≤40%
H - Hypertension (1 point)
- Resting blood pressure >140/90 mmHg on at least two occasions, OR
- Current antihypertensive treatment
- Optimal BP target: 120-129/70-79 mmHg
A - Age ≥75 years (2 points)
- Age is an independent determinant of ischemic stroke risk
- Two points given for age 75 years or above
D - Diabetes Mellitus (1 point)
- Type 1 or type 2 diabetes by currently accepted criteria, OR
- Treatment with glucose-lowering therapy
S - Prior Stroke/TIA/Arterial Thromboembolism (2 points)
- Previous thromboembolism carries highly elevated recurrence risk
- Weighted as 2 points due to high-risk nature
V - Vascular Disease (1 point)
- Coronary artery disease including:
- Prior myocardial infarction
- Angina
- History of coronary revascularization (surgical or percutaneous)
- Significant CAD on angiography or cardiac imaging
A - Age 65-74 years (1 point)
- One point for age between 65 and 74 years
Key Differences from CHA₂DS₂-VASc
The critical distinction is the removal of female sex as a scoring criterion. The 2024 ESC Guidelines explicitly state this score is "without a criterion for birth sex or gender" 1. This modification reflects emerging evidence that female sex functions more as a risk modifier rather than an independent risk factor 2, with recent data showing attenuated sex-based differences in stroke risk over time 3.
Clinical Application
Oral anticoagulation is recommended for CHA₂DS₂-VA score ≥2 and should be considered for score of 1 1. The score ranges from 0 to 9 points total, with higher scores indicating progressively elevated thromboembolic risk requiring anticoagulation therapy.
Important Caveats
- Beyond these seven components, consider additional risk modifiers including cancer, chronic kidney disease, ethnicity (Black, Hispanic, Asian), and biomarkers (troponin, BNP) 1
- Certain conditions mandate anticoagulation regardless of score: hypertrophic cardiomyopathy and cardiac amyloidosis require OAC independent of CHA₂DS₂-VA calculation 1
- Periodic reassessment of thromboembolic risk is essential to ensure appropriate anticoagulation decisions 1