Is vaginal itching a side effect of Zepbound (generic name)?

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Last updated: June 6, 2025View editorial policy

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From the Guidelines

Vaginal itching is not a commonly reported side effect of Zepbound (tirzepatide). Zepbound is primarily used for weight management and contains tirzepatide, which works by mimicking certain hormones that regulate appetite and blood sugar. The most common side effects of Zepbound include gastrointestinal issues such as nausea, diarrhea, vomiting, constipation, and abdominal pain. Other reported side effects include fatigue, injection site reactions, hair loss, and changes in taste. If you're experiencing vaginal itching while taking Zepbound, it's more likely due to another cause such as a yeast infection, allergic reaction to hygiene products, or other medical conditions, as suggested by studies on vulvovaginal candidiasis 1.

Possible Causes of Vaginal Itching

  • Yeast infection, which can be caused by Candida species, as discussed in the clinical practice guideline for the management of candidiasis 1
  • Allergic reaction to hygiene products
  • Other medical conditions, such as those that affect the vaginal pH, as mentioned in the study on sexually transmitted diseases treatment guidelines 1

Importance of Consulting a Healthcare Provider

It's essential to consult with your healthcare provider about this symptom, as they can determine the actual cause and recommend appropriate treatment. Don't stop taking Zepbound without discussing it with your doctor first, as the medication is important for your prescribed treatment plan. The healthcare provider can also consider the latest guidelines for the management of candidiasis, as updated in 2009 by the Infectious Diseases Society of America 1.

Key Takeaway

Vaginal itching is not a direct side effect of Zepbound, and its cause should be investigated by a healthcare provider. If you're experiencing vaginal itching, it's crucial to consult with your healthcare provider to determine the underlying cause and receive proper treatment, as the symptom can be related to various conditions, including vulvovaginal candidiasis, as discussed in the review of the evidence for the 2021 Centers for Disease Control and Prevention of sexually transmitted infections treatment guidelines 1.

From the Research

Vaginal Itching as a Side Effect of Zepbound

  • There is no direct evidence in the provided studies that links Zepbound to vaginal itching as a side effect.
  • However, the studies discuss various causes of vaginal itching, including bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis 2, 3, 4.
  • Treatment options for these conditions are also discussed, including oral and topical antifungal and antibacterial agents 2, 3, 5, 6.
  • It is essential to note that Zepbound is not mentioned in any of the provided studies, and therefore, its potential side effects, including vaginal itching, cannot be determined from this evidence.
  • Further research would be necessary to determine if Zepbound is associated with vaginal itching as a side effect 2, 3, 5, 4, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Vaginitis: Diagnosis and Treatment.

American family physician, 2018

Research

Antimicrobial topical agents used in the vagina.

Current problems in dermatology, 2011

Research

Treatment of vaginal candidiasis: orally or vaginally?

Journal of the American Academy of Dermatology, 1990

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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