What is the recommended treatment for otitis media in adults?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

The recommended treatment for otitis media in adults typically begins with antibiotics, with amoxicillin-clavulanate being a suitable option, as noted in a study from 2003 1.

Treatment Options

  • For patients with penicillin allergies, alternatives may be considered, but the most recent and highest quality study on otitis media treatment, from 2017, emphasizes the importance of accurate diagnosis and optimal management of ear pain 1.
  • Pain management is essential and can include acetaminophen or ibuprofen, with decongestants like pseudoephedrine potentially helping to relieve ear pressure.
  • The choice of antibiotic should be based on the most recent guidelines, which suggest that amoxicillin-clavulanate is an appropriate choice for adults with otitis media, as supported by a 2004 study on antimicrobial treatment guidelines for acute bacterial rhinosinusitis 1.

Key Considerations

  • Patients should complete the full course of antibiotics even if symptoms improve, and follow up if symptoms worsen or don't improve within 48-72 hours of treatment.
  • For severe cases or those unresponsive to oral antibiotics, referral to an ENT specialist may be necessary for tympanocentesis or more aggressive treatment.
  • The most recent study from 2017 highlights the importance of reducing the burden of otitis media and making decisions based on the best available evidence 1.

From the FDA Drug Label

CLINICAL STUDIES SECTION Pediatric Patients ... Acute Otitis Media Safety and efficacy using azithromycin 30 mg/kg given over 5 days ...

The FDA drug label does not answer the question.

From the Research

Recommended Treatment for Otitis Media in Adults

  • The management of otitis media with effusion in adults is an area that requires a rethink, with ventilation tubes being associated with disappointing outcomes and significant complications 2.
  • Alternatives to ventilation tubes, such as balloon dilatation of the Eustachian tube, intratympanic steroid therapy, and cortical mastoidectomy, appear to be possible options for the management of otitis media with effusion in adults 2.
  • For cases not associated with nasopharyngeal carcinoma, intratympanic steroid therapy appears to be a promising option for the management of otitis media with effusion in adults 2.
  • Acute otitis media is usually a complication of eustachian tube dysfunction that occurs during a viral upper respiratory tract infection, and management should begin with adequate analgesia 3, 4.
  • High-dose amoxicillin is the antibiotic of choice for treating acute otitis media in patients who are not allergic to penicillin, although the effectiveness of antibiotics in adults is not well established 3, 4.

Analgesia and Antibiotic Therapy

  • Adequate analgesia should be prescribed in all cases of acute otitis media 3, 4.
  • Antibiotic therapy can be deferred in children two years or older with mild symptoms, but the effectiveness of this approach in adults is not well established 3, 4.
  • Amoxicillin-clavulanate and trimethoprim-sulfamethoxazole are alternative antibiotic options for the treatment of acute otitis media, although their effectiveness in adults is not well established 5.

Limitations of Current Evidence

  • There is limited evidence on the effectiveness of paracetamol or NSAIDs, alone or combined, in relieving pain in adults with acute otitis media 6.
  • Further research is needed to provide insights into the role of ibuprofen as adjunct to paracetamol, and other analgesics such as anaesthetic eardrops, for adults with acute otitis media 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Management of otitis media with effusion in adults.

The Journal of laryngology and otology, 2025

Research

Otitis media: diagnosis and treatment.

American family physician, 2013

Research

Diagnosis and treatment of acute otitis media: review.

The Journal of laryngology and otology, 2012

Research

Twice-daily antibiotics in the treatment of acute otitis media: trimethoprim-sulfamethoxazole versus amoxicillin-clavulanate.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1990

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.