Does Xanax (alprazolam) need to be separated from metoprolol when taken together?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: June 7, 2025 • View editorial policy

From the Research

Xanax (alprazolam) and metoprolol can generally be taken together as there is no significant interaction that requires separating their administration times. These medications work through different mechanisms in the body - Xanax affects GABA receptors in the brain to reduce anxiety, while metoprolol blocks beta receptors to lower blood pressure and heart rate. However, patients should be aware that both medications can cause drowsiness, dizziness, and lightheadedness, so these side effects may be enhanced when taken together. It's essential to take both medications exactly as prescribed by your doctor, as changing doses or timing could affect how well they work. If you experience increased sedation, significant drops in blood pressure, or unusual dizziness after taking these medications together, contact your healthcare provider promptly. Always inform all your healthcare providers about all medications you're taking to ensure safe treatment and proper monitoring, as noted in studies such as 1 and 2. Additionally, metoprolol's interactions with other medications have been studied, as seen in 3, but its interaction with alprazolam is not significant in terms of requiring separated administration times. The most recent study 4 does not directly address the interaction between metoprolol and alprazolam but highlights the importance of monitoring for adverse events when metoprolol is used, which can be applied to its use with other medications like alprazolam. Key points to consider when taking these medications together include:

  • Monitoring for enhanced side effects like drowsiness and dizziness
  • Adhering to prescribed doses and administration times
  • Informing healthcare providers about all medications being taken
  • Being aware of potential interactions, even if they are not directly significant between metoprolol and alprazolam, as noted in 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.