Prozac Formulations
Yes, Prozac (fluoxetine) is available in tablet form, though the original and most commonly prescribed formulation is the capsule (Pulvule®). 1
Available Formulations
According to the FDA drug label, Prozac comes in multiple formulations 1:
- Capsules (Pulvules®): Available in 10 mg, 20 mg, and 40 mg strengths
- Oral solution: 20 mg/5 mL liquid formulation containing 0.23% alcohol
- Delayed-release capsules (Prozac Weekly™): 90 mg enteric-coated pellets for once-weekly dosing
Tablet Availability
While the FDA label describes capsules and oral solution as the standard formulations 1, generic fluoxetine tablets have been developed and proven bioequivalent to the original Prozac capsules 2. A 2006 bioequivalence study demonstrated that fluoxetine 20 mg tablets met FDA criteria for bioequivalence to Prozac capsules, with 90% confidence intervals for both AUC and Cmax falling within the required 80-125% range 2.
Additional research confirms that dispersible tablet formulations of fluoxetine hydrochloride are also bioequivalent to reference capsule formulations 3.
Clinical Implications
- All formulations are bioequivalent, meaning tablets, capsules, and oral solution deliver the same therapeutic effect
- Food does not affect bioavailability of any formulation, though it may delay absorption by 1-2 hours (not clinically significant) 1
- The choice between tablet and capsule is primarily a matter of patient preference and availability
- Generic tablet formulations are well-tolerated with no difference in adverse event profiles compared to branded capsules 2