What is the best way to prevent Delayed Onset Muscle Soreness (DOMS)?

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Last updated: June 7, 2025View editorial policy

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From the Guidelines

The best way to prevent Delayed Onset Muscle Soreness (DOMS) is to consume adequate protein, specifically 20-25g of high-quality protein at 3-4 hour intervals, and maintain a daily carbohydrate intake of 6-8g/kg body weight for up to 48-72 hours after exercise. This approach is supported by the most recent and highest quality study available, which emphasizes the importance of proper nutrition in recovery from exercise 1.

To further reduce the risk of DOMS, it is essential to:

  • Gradually progress exercise intensity to allow muscles to adapt
  • Perform a proper warm-up routine before exercising
  • Stay well-hydrated before, during, and after exercise
  • Consider consuming 30-60g of casein protein prior to sleep to enhance overnight protein synthesis, as suggested by emerging evidence 1

It is also important to note that while some studies have reported reductions in muscle soreness with postexercise intake of protein or branched chain amino acids, the overall effects are small 1. Additionally, consuming polyphenol-rich tart cherry juice has not been shown to improve recovery markers of function or subjective soreness in football players 1, and reducing exercise-induced muscle inflammation and free radical production with large doses of individual antioxidant vitamins C and E may interfere with adaptive processes in muscle and is therefore discouraged 1.

From the Research

Prevention Strategies for Delayed Onset Muscle Soreness (DOMS)

To prevent DOMS, several strategies can be employed, including:

  • Eccentric exercise introduction: Gradually introducing eccentric exercises or novel activities over a period of 1 or 2 weeks can help reduce the level of physical impairment and/or training disruption 2
  • BCAA supplementation: Branched-chain amino acid (BCAA) supplementation has been shown to attenuate exercise-induced muscle damage and DOMS, with repeated BCAA supplementation before exercise having a more beneficial effect than repeated supplementation after exercise 3, 4
  • Combination of BCAA and taurine: A combination of 3.2 g BCAA and 2.0 g taurine, three times a day, for two weeks prior to and three days after exercise may be a useful nutritional strategy for attenuating exercise-induced DOMS and muscle damage 5
  • Exercise modification: Reducing the intensity and duration of exercise for 1-2 days following intense DOMS-inducing exercise, or targeting less affected body parts, can help alleviate DOMS symptoms 2

Treatment Considerations

Treatment considerations for DOMS focus on:

  • Primary prevention of ultrastructural lesions during exercise
  • Treatment of the inflammatory response that leads to DOMS
  • Recovery strategies for manifest DOMS 6 Nonsteroidal anti-inflammatory drugs, massage, and exercise have demonstrated varying results in alleviating DOMS symptoms, while cryotherapy, stretching, homeopathy, ultrasound, and electrical current modalities have shown no effect 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Effect of branched-Chain Amino Acid Supplementation on Muscle Soreness following Exercise: A Meta-Analysis.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2019

Research

Advances in Delayed-Onset Muscle Soreness (DOMS) - Part II: Treatment and Prevention.

Sportverletzung Sportschaden : Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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