From the Research
The recommended dose of Teicoplanin for patients with normal renal function is 12 mg/kg at 12-hour intervals, while for those with impaired renal function, the dose should be adjusted to 9.5,6, and 4 mg/kg at 12-hour intervals for mild, moderate, and severe renal impairment, respectively, as supported by the most recent study 1.
Key Considerations
- Teicoplanin is a glycopeptide antibiotic that works by inhibiting bacterial cell wall synthesis.
- Proper dosing ensures adequate antimicrobial activity while minimizing nephrotoxicity risk.
- The dose adjustment for patients with impaired renal function is crucial to avoid toxicity and ensure efficacy.
Dosing Recommendations
- For patients with normal renal function: 12 mg/kg at 12-hour intervals 1.
- For patients with mild renal impairment: 9.5 mg/kg at 12-hour intervals 1.
- For patients with moderate renal impairment: 6 mg/kg at 12-hour intervals 1.
- For patients with severe renal impairment: 4 mg/kg at 12-hour intervals 1.
Therapeutic Drug Monitoring
- Aiming for trough concentrations of 10-20 mg/L for most infections and 20-60 mg/L for more severe infections like endocarditis is advisable 2.
Renal Function Considerations
- The estimated glomerular filtration rate (eGFR) is a significant covariate in the population pharmacokinetics model of teicoplanin, and dose adjustment should be based on eGFR 1.
- For patients with creatinine clearance below 40 mL/min, reducing the maintenance dose or extending the dosing interval may be necessary to avoid nephrotoxicity 3.