Semaglutide Storage at Room Temperature
Semaglutide injection can be kept at room temperature (8°C to 30°C or 46°F to 86°F) for up to 28 days prior to cap removal. 1
Storage Guidelines
The FDA-approved labeling for Wegovy (semaglutide) provides explicit storage instructions:
- Primary storage: Refrigerate at 2°C to 8°C (36°F to 46°F)
- Room temperature allowance: If needed, the pen can be kept at 8°C to 30°C (46°F to 86°F) for up to 28 days before the cap is removed 1
- Do not freeze
- Protect from light - keep in original carton until administration
- Discard after use 1
Critical Caveats
The 28-day room temperature window applies only before the cap is removed. This is a single-dose pen that must be discarded after one use, so the practical implication is that you have flexibility in storage conditions during the 28 days leading up to administration.
Common pitfall: Do not confuse this with multi-dose vials that may have different in-use stability requirements. Wegovy/Ozempic pens are single-dose devices designed for one-time use 1.
Practical Application
For patients traveling or unable to maintain consistent refrigeration:
- The medication tolerates room temperature exposure for nearly a month
- Always return to refrigeration when possible for optimal stability
- Never expose to freezing temperatures
- Maintain light protection by keeping in the original carton 1
This storage flexibility makes semaglutide practical for real-world use, including travel scenarios, without compromising drug stability or efficacy.