Epidermoid cyst: A benign, usually small, lump that can appear on the scrotum. It is filled with keratin, a protein found in skin cells, and is often harmless.

Sebaceous cyst: Similar to an epidermoid cyst but originates from the sebaceous glands. It can also present as a small, usually painless, lump on the scrotum.
Pearly penile papule: Although more common on the penis, these small, benign bumps can occasionally be found on the scrotum.
Folliculitis: An inflammation of the hair follicles, which can cause small bumps on the scrotum, especially if there is an ingrown hair or infection.
Angiokeratoma: A small, dark, vascular lesion that can appear on the scrotum, often benign but can be part of a systemic condition in rare cases.

Testicular cancer: Although rare, any new lump on the scrotum or testicle should be evaluated for the possibility of testicular cancer, which can present as a painless lump.
Scrotal cellulitis or abscess: An infection of the scrotal skin or tissues, which can cause redness, swelling, and bumps. It requires prompt medical attention to prevent serious complications.
Malignant melanoma: Although extremely rare on the scrotum, any new or changing pigmented lesion should be evaluated for melanoma due to its potential for aggressive behavior.

Scrotal calcinosis: A rare condition characterized by the deposition of calcium in the scrotal skin, leading to small, hard bumps.
Neurofibroma: A rare benign tumor of the nerve tissue that can occur on the scrotum, more commonly in individuals with neurofibromatosis.
Scrotal lymphangioma: A rare congenital condition that can cause soft, painless masses on the scrotum due to malformations of the lymphatic vessels.