INSEMA Trial Access
The full INSEMA trial publication is available in the New England Journal of Medicine (2024), and you can access it through medical libraries, institutional subscriptions, or directly from the journal's website.
Primary Publication Details
The primary results of the INSEMA (Intergroup Sentinel Mamma) trial were published by Reimer et al. in the New England Journal of Medicine in 2024 1. This is the definitive source for the complete trial methodology, results, and analysis.
Additional INSEMA Publications Available
Beyond the primary publication, several secondary analyses and related papers from the INSEMA trial are publicly accessible:
Secondary Outcomes and Analyses:
Axillary surgery in sentinel node macrometastases - Published in NPJ Breast Cancer (2026), reporting results from the second randomization comparing completion axillary lymph node dissection versus sentinel lymph node biopsy alone 2
Patient-reported outcomes - Published in EClinicalMedicine (2023), presenting comprehensive quality of life data including arm and breast symptoms 3
Initial trial design and early results - Published in Geburtshilfe und Frauenheilkunde (2017), describing the trial protocol and first 1001 patients 4
Real-World Applications:
German multicenter analysis - Published in European Journal of Surgical Oncology (2025), examining real-world implications at three university breast cancer centers 5
Australian and New Zealand applicability - Published in ANZ Journal of Surgery (2026), evaluating relevance of INSEMA criteria in this population 6
How to Access
Direct access options:
- PubMed/MEDLINE database (search: "INSEMA trial" or "NCT02466737")
- New England Journal of Medicine website (primary publication)
- Institutional library subscriptions
- ClinicalTrials.gov registry (NCT02466737) for protocol and summary results
The trial registration (NCT02466737) on ClinicalTrials.gov provides the complete protocol, statistical analysis plan, and summary results as required by reporting standards 7, 8, 9.