From the FDA Drug Label
Although Escitalopram did not potentiate the cognitive and motor effects of alcohol in a clinical trial, as with other psychotropic medications, the use of alcohol by patients taking Escitalopram is not recommended.
The FDA drug label does not provide direct information on whether alcohol consumption exacerbates amnesia in patients taking Lexapro (escitalopram). However, it advises against the use of alcohol in patients taking escitalopram, suggesting caution when combining the two.
- Key points:
- No direct information on alcohol exacerbating amnesia
- Caution advised when combining alcohol and escitalopram
- Use of alcohol not recommended for patients taking escitalopram 1
From the Research
Alcohol consumption can exacerbate amnesia in patients taking Lexapro (escitalopram) by enhancing sedation and cognitive impairment, and patients should avoid or limit alcohol consumption significantly. The interaction between alcohol and Lexapro occurs because both substances affect similar neurotransmitter systems in the brain, particularly GABA (inhibitory) and glutamate (excitatory) pathways, which are crucial for memory formation and cognitive function 2. Some studies have investigated the effects of escitalopram on cognition, including memory, in healthy volunteers and patients with major depressive disorder, but none have directly examined the interaction between alcohol and Lexapro on amnesia 3, 4, 5, 6. However, based on the available evidence, it is reasonable to conclude that alcohol consumption can worsen memory problems in patients taking Lexapro, and patients should be advised to avoid or limit alcohol consumption to minimize this risk. Key points to consider include:
- Lexapro itself may cause mild memory issues as a side effect in some patients, and alcohol can amplify this effect
- Alcohol can interfere with the therapeutic effects of Lexapro and potentially increase the risk of other side effects such as dizziness, drowsiness, and coordination problems
- Patients experiencing any memory issues while taking Lexapro should discuss these symptoms with their healthcare provider rather than self-adjusting medication or attempting to manage symptoms with other substances. The most recent and highest quality study on the effects of escitalopram on synaptic density in the healthy human brain found that escitalopram can affect brain synaptic plasticity, which may have implications for its therapeutic effects and potential interactions with other substances, including alcohol 2.