From the FDA Drug Label
A small amount of mupirocin ointment should be applied to the affected area three times daily. The recommended dosage of mupirocin is a small amount and the recommended frequency is three times daily.
- Application: to the affected area
- Coverage: may be covered with a gauze dressing if desired
- Re-evaluation: if no clinical response within 3 to 5 days 1
From the Research
For treating groin folliculitis, mupirocin 2% ointment is typically applied to the affected area 2-3 times daily for 7-10 days. Use a thin layer of the ointment on clean, dry skin after gently washing the area with mild soap and water. Before each application, it's advisable to cleanse the area to remove any debris or exudate. Mupirocin works by inhibiting bacterial protein synthesis, effectively targeting Staphylococcus aureus and Streptococcus species which commonly cause folliculitis, as supported by a study published in The British journal of clinical practice 2.
Key Considerations
- The most recent and highest quality study on the topic of bacterial folliculitis and boils, published in The Cochrane database of systematic reviews in 2021, did not specifically address the use of mupirocin for folliculitis but highlighted the importance of topical antibiotics in treating such infections 3.
- An older study from 1989 published in Cutis also discussed the efficacy of mupirocin 2% ointment in treating primary and secondary skin infections, including its potential as an alternative to oral antibiotics due to fewer adverse effects and lower cost 4.
- However, the primary consideration for treating groin folliculitis with mupirocin 2% ointment should be based on the most recent evidence available, which, although not directly addressing mupirocin's use for this specific condition, supports the use of topical antibiotics for similar infections.
Application and Precautions
- Apply a thin layer of mupirocin 2% ointment to the affected area 2-3 times daily.
- Ensure the area is clean and dry before application.
- Complete the full course of treatment, even if symptoms improve earlier, to prevent recurrence.
- If symptoms persist or worsen, consult a healthcare provider, as this may indicate a deeper infection requiring oral antibiotics.
- Avoid covering the treated area with tight clothing or bandages unless directed by a healthcare provider, to prevent trapping moisture and potentially worsening the infection.
Evidence Summary
The recommendation for using mupirocin 2% ointment for treating groin folliculitis is based on its efficacy against common causative bacteria of skin infections, as demonstrated in earlier studies 2, 4, and the general principles of treating bacterial folliculitis and boils with topical antibiotics, as discussed in more recent reviews 3. However, it's crucial to follow the specific application guidelines and monitor for any signs of worsening infection or adverse reactions.