From the Research
The maximum lacosamide dose for pediatric patients is generally 12 mg/kg/day, not to exceed 400 mg per day, as supported by the most recent study 1.
Key Considerations
- The dose should be adjusted according to the child's weight, with careful monitoring for side effects such as dizziness, headache, and nausea.
- Lacosamide is used as an adjunctive therapy for partial-onset seizures in children 4 years and older.
- For children under 4 years of age, the dose may need to be adjusted based on age, with infants between 1 month and 1 year of age potentially requiring higher doses of 15 to 18 mg/kg/d 1.
Dosing Recommendations
- Initiate dosing at a lower level and gradually increase to the maximum dose based on clinical response and tolerability.
- For children weighing 50 kg or more, the adult maximum dose of 400 mg/day applies.
- The dose should be given in two divided doses, with careful monitoring for side effects.
Supporting Evidence
- A pharmacometric analysis of real-world data supported the use of 12 mg/kg/day in children ≥4 years of age, with higher doses potentially needed in younger children 1.
- Clinical trials have demonstrated the safety and efficacy of lacosamide in pediatric patients with focal seizures, with a maximum dose of 12 mg/kg/day not to exceed 400 mg per day 2.