What topical treatments are used for skin allergies (allergic dermatitis)?

From the Guidelines

For skin allergies, topical corticosteroids (TCS) are the most commonly utilized FDA-approved therapies and should be used as first-line treatment for mild-to-severe dermatitis in all skin regions. According to the most recent guidelines 1, TCS are grouped into 7 classes based on potency, and the choice of steroid potency should consider the anatomical site. For example, lower potency agents should be used on sensitive areas.

Some key points to consider when using topical treatments for skin allergies include:

• Applying a thin layer of the chosen product to clean, dry skin and gently rubbing it in
• Using the product up to four times a day, as needed
• Considering alternative treatments, such as calamine lotion or antihistamine cream containing diphenhydramine, for itch relief
• Always reading and following the product instructions, and discontinuing use if irritation occurs

It's also important to note that for severe or persistent skin allergies, consulting a doctor is necessary, as stronger prescription medications may be required 1. Additionally, emollients and prescription topical therapies are often sufficient to achieve control of atopic dermatitis, but phototherapy or systemic therapies may be considered for more severe cases 1.

In terms of specific treatments, the guidelines mention the use of topical anti-inflammatory medications, including corticosteroids and calcineurin inhibitors 1. However, the most recent and highest quality study 1 prioritizes the use of TCS as the first-line treatment for skin allergies.

From the FDA Drug Label

Uses temporarily relieves itching associated with minor skin irritations, inflammation, and rashes due to: eczema psoriasis poison ivy, oak, sumac insect bites detergents jewelry cosmetics soaps seborrheic dermatitis Directions for itching of skin irritation, inflammation, and rashes: adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily Purpose Anti-itch

The topical treatment used for skin allergies (allergic dermatitis) is hydrocortisone. It is used to temporarily relieve itching associated with minor skin irritations, inflammation, and rashes due to various causes, including eczema and insect bites 2. The application instructions for hydrocortisone topical treatment are to apply to the affected area not more than 3 to 4 times daily for adults and children 2 years of age and older 2. The primary purpose of this treatment is as an anti-itch medication 2.

• Key uses: eczema, psoriasis, poison ivy, oak, sumac, insect bites, detergents, jewelry, cosmetics, soaps, seborrheic dermatitis
• Application instructions: apply to affected area not more than 3 to 4 times daily
• Age restrictions: children under 2 years of age and children under 12 years of age for external anal and genital itching should ask a doctor 2

From the Research

Topical Treatments for Skin Allergies

Topical treatments are commonly used to manage skin allergies, also known as allergic dermatitis. The following are some of the topical treatments used:

• Hydrocortisone cream, a topical corticosteroid, is widely recommended by physicians and used by patients to treat skin allergies 3, 4, 5, 6
• Sertaconazole 2% cream, an antifungal medication, has been shown to be effective in treating facial seborrheic dermatitis, a type of skin allergy 4
• Emollient creams, such as those containing urea and glycerol, can help soften and soothe the skin, reducing dryness and irritation 7
• Moisturizers, including those with anti-microbial and anti-oxidant properties, can help repair the skin's barrier function and reduce inflammation 7

Characteristics of Topical Treatments

The characteristics of topical treatments can vary, including:

• Potency: Topical corticosteroids come in different potency classes, and selecting the appropriate potency is important for effective treatment 6
• Vehicle: The vehicle of a topical treatment can affect its efficacy and patient preferences 6
• Frequency of application: The frequency of application can impact the effectiveness of a topical treatment 6
• Duration of treatment: The duration of treatment can vary depending on the severity of the skin allergy and the response to treatment 6

Safety and Efficacy

The safety and efficacy of topical treatments for skin allergies have been studied, with results showing:

• Hydrocortisone 1% cream is safe and effective in treating facial seborrheic dermatitis 4
• A cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol is well-tolerated and non-toxic in human subjects 5
• Different types of emollient creams can have diverse physiological effects on the skin barrier in adults with atopic dermatitis 7