Are there over-the-counter (OTC) remedies for Urinary Tract Infections (UTIs)?

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Last updated: February 24, 2025View editorial policy

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From the Guidelines

Yes, there are over-the-counter remedies that can help alleviate symptoms of a urinary tract infection (UTI), but they do not cure the infection itself. The most common OTC option is phenazopyridine (sold under brand names like AZO or Uristat), which can relieve pain, burning, and urgency. The typical dose is 200mg taken orally three times a day for up to two days. It's essential to note that this medication only masks symptoms and does not treat the underlying bacterial infection. Other OTC options include taking pain relievers like ibuprofen to reduce discomfort and drinking plenty of water to help flush out bacteria. Some people find cranberry supplements or drinking unsweetened cranberry juice helpful, though scientific evidence for their effectiveness is mixed, as shown in a study published in The Journal of Urology 1. While these remedies can provide temporary relief, it's crucial to see a healthcare provider for proper diagnosis and treatment, typically with antibiotics, as untreated UTIs can lead to more serious kidney infections. According to a recent study published in Annals of Internal Medicine 1, the American College of Physicians recommends short-course antibiotics for uncomplicated UTIs, such as nitrofurantoin for 5 days, trimethoprim–sulfamethoxazole for 3 days, or fosfomycin as a single dose. Also, be aware that phenazopyridine can cause orange discoloration of urine and may stain clothing. Key points to consider when treating UTIs include:

  • Drinking plenty of water to help flush out bacteria
  • Taking pain relievers like ibuprofen to reduce discomfort
  • Using OTC options like phenazopyridine to relieve pain, burning, and urgency
  • Seeking medical attention for proper diagnosis and treatment with antibiotics, as recommended by the American College of Physicians 1.

From the FDA Drug Label

Phenazopyridine HCl is indicated for the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters The answer is yes, there are over-the-counter (OTC) remedies for Urinary Tract Infections (UTIs), such as phenazopyridine, which provides symptomatic relief of pain and discomfort. However, it is essential to note that:

  • The use of phenazopyridine should not delay definitive diagnosis and treatment of the causative condition.
  • Phenazopyridine should be discontinued when symptoms are controlled.
  • Treatment with phenazopyridine should not exceed 2 days 2.

From the Research

Over-the-Counter (OTC) Remedies for Urinary Tract Infections (UTIs)

  • There is no direct evidence of OTC remedies for UTIs in the provided studies 3, 4, 5, 6, 7.
  • The studies focus on the diagnosis, treatment, and prevention of UTIs, recommending antibiotics such as fosfomycin, nitrofurantoin, and trimethoprim/sulfamethoxazole as first-line treatments 3, 4, 6, 7.
  • However, some studies mention that asymptomatic bacteriuria does not need to be treated, and that urine cultures should be obtained in complicated or upper UTIs 3, 5, 7.
  • The use of dipstick urinalysis and microscopic urinalysis is also discussed as a diagnostic tool, but not as a treatment option 5, 7.

Treatment Options

  • The recommended treatment options for UTIs include:
    • Fosfomycin
    • Nitrofurantoin
    • Trimethoprim/sulfamethoxazole (in regions where the prevalence of Escherichia coli resistance does not exceed 20 percent) 3, 4, 6, 7
  • Beta-lactam antibiotics, amoxicillin/clavulanate, cefaclor, cefdinir, and cefpodoxime are not recommended for initial treatment due to concerns about resistance 6.
  • In pregnancy, beta-lactams, nitrofurantoin, fosfomycin, and trimethoprim/sulfamethoxazole can be appropriate treatments 7.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The Emergency Department Diagnosis and Management of Urinary Tract Infection.

Emergency medicine clinics of North America, 2018

Research

Diagnosis and treatment of acute uncomplicated cystitis.

American family physician, 2011

Research

Diagnosis and treatment of urinary tract infections across age groups.

American journal of obstetrics and gynecology, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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