From the Guidelines
The most effective treatment for yeast infection of skin folds is the application of topical azoles and polyenes, including clotrimazole, miconazole, and nystatin, along with keeping the area dry. This approach is supported by the Infectious Diseases Society of America's practice guidelines for the treatment of candidiasis 1. Key considerations in managing these infections include:
- Applying topical antifungal medications to the affected areas
- Keeping the skin folds dry to prevent the growth of yeast
- Addressing underlying factors such as obesity and diabetes that may contribute to the development of these infections
- Using absorbent powders like cornstarch to reduce moisture in the skin folds
- Wearing loose-fitting, breathable clothing to prevent recurrence
The guidelines for treatment of candidiasis also emphasize the importance of drainage for paronychia, but for skin fold infections, topical treatment and dryness are paramount 1. It's crucial to note that while multiple studies support the use of topical azoles and polyenes, the most recent and highest quality study should guide clinical decision-making. However, given the provided evidence, topical azoles and polyenes remain the recommended treatment, with the addition of lifestyle modifications to keep the area dry and manage underlying health conditions.
From the FDA Drug Label
INDICATIONS AND USAGE Nystatin Topical Powder is indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. The treatment for yeast infection of skin folds is Nystatin Topical Powder as it is indicated for cutaneous mycotic infections caused by Candida albicans and other susceptible Candida species 2.
- Key points:
- Cutaneous infections are those affecting the skin
- Mycotic infections are those caused by fungi, including yeast
- Candida albicans is a common cause of yeast infections
- Nystatin Topical Powder is not for systemic, oral, intravaginal, or ophthalmic use.
From the Research
Treatment Options for Yeast Infection of Skin Folds
- Topical antifungal agents such as clotrimazole, miconazole, and nystatin are effective in treating cutaneous candidiasis, including yeast infections of skin folds 3, 4.
- These agents have shown similar efficacy, with complete cure rates of 73%-100% 4.
- Oral antifungal agents such as fluconazole can also be used to treat cutaneous candidiasis, including yeast infections of skin folds 5, 4.
- Fluconazole has been shown to be as effective as topical clotrimazole in treating cutaneous candidiasis 4.
Choosing a Treatment
- The choice of treatment depends on the severity and location of the infection, as well as the patient's preferences and medical history.
- Topical treatments are often preferred for localized infections, while oral treatments may be necessary for more widespread or severe infections 6, 4.
- The cost and availability of different treatments can also be a factor in choosing a treatment 6.
Specific Treatments
- Clotrimazole, nystatin, and miconazole are commonly used topical treatments for yeast infections of skin folds 3, 4.
- Fluconazole is a commonly used oral treatment for cutaneous candidiasis, including yeast infections of skin folds 5, 4.
- Other treatments, such as itraconazole and terbinafine, may also be effective in treating yeast infections of skin folds, but may not be as well-studied as clotrimazole, nystatin, and miconazole 5, 6.