Differential Diagnosis for White Lesion Chronic in the Scrotum

• Single Most Likely Diagnosis
  • Leukoplakia: This condition is characterized by a white patch or plaque that cannot be rubbed off and is often associated with chronic irritation or inflammation. It's a common finding in the scrotal area and can be a precursor to more serious conditions, but in itself, it's often benign.
• Other Likely Diagnoses
  • Lichen sclerosus: A chronic inflammatory skin condition that can cause white, patchy skin that's thinner than normal. It's known to affect the genital and anal areas, including the scrotum.
  • Lichen planus: An inflammatory condition that can affect the skin and mucous membranes, leading to white, lacy patches. It can occur in the genital area, including the scrotum.
  • Scleroderma: A condition where the skin becomes tightened and hardened, which can lead to white, leathery patches. Though less common in the scrotum, it's a consideration.
• Do Not Miss Diagnoses
  • Squamous cell carcinoma: Although less likely, any chronic lesion, especially those that are white and persistent, should raise concern for malignancy. Squamous cell carcinoma can present as a white lesion and is critical to diagnose early.
  • Extramammary Paget's disease: A rare skin malignancy that can present as a white, eczematous patch in the genital area, including the scrotum. It's crucial to consider due to its potential for malignancy.
• Rare Diagnoses
  • Vitiligo: While more commonly associated with loss of pigmentation, in some cases, it can present with white patches that might be confused with other conditions.
  • Pachydermia: A condition characterized by thickening of the skin, which can sometimes appear as white, thickened areas. It's less common in the scrotal area but should be considered in the differential diagnosis of chronic white lesions.