Answer
Direct human-bat contact 1.
- Rationale:
- The most recent, high-quality evidence indicates that zoonotic spillover is facilitated when humans have direct contact with bats or their secretions, enabling cross-species transmission—particularly by enveloped viruses with higher zoonotic propensity 1.
- Rabies prevention guidelines also flag any direct human-bat contact as a potential exposure needing evaluation, underscoring contact as the key transmission bridge with serious morbidity and mortality implications 2.