From the FDA Drug Label
Serum calcium concentration is not affected by amlodipine.
The labs to monitor for patients on amlodipine are not explicitly stated in the drug label. However, based on the information provided, it can be inferred that:
- Serum calcium levels do not need to be monitored as amlodipine does not affect serum calcium concentration.
- No other specific labs are mentioned in the label as being necessary to monitor for patients on amlodipine. 1
From the Research
For patients on amlodipine, regular monitoring should include blood pressure, heart rate, electrolytes (particularly potassium, sodium, and calcium), renal function tests (BUN and creatinine), and liver function tests.
Monitoring Parameters
The monitoring parameters for patients on amlodipine are crucial for ensuring the safe and effective use of the medication.
- Blood pressure and heart rate should be checked at baseline and periodically throughout treatment to ensure the medication is effectively controlling hypertension without causing excessive hypotension 2.
- Electrolyte levels are important because calcium channel blockers can occasionally affect calcium metabolism.
- Renal function monitoring is necessary as amlodipine is partially eliminated by the kidneys, and any decline in kidney function may require dosage adjustments 3.
- Liver function tests are recommended because amlodipine is metabolized by the liver, and impaired liver function could lead to drug accumulation.
Additional Considerations
Additionally, patients should be monitored for peripheral edema, particularly in the ankles and feet, which is a common side effect of amlodipine 4.
- For elderly patients or those with pre-existing cardiac conditions, monitoring for signs of heart failure exacerbation is also prudent.
- The most recent study 2 supports the effectiveness of amlodipine in controlling blood pressure, which is essential for minimizing the risk of cardiovascular events and delaying the progression of renal disease. These monitoring parameters help ensure the safe and effective use of amlodipine while minimizing potential adverse effects.