From the Research
There is no documented interaction between donepezil and cilostazol in the provided evidence, but caution is advised due to potential increased risk of gastrointestinal side effects. When considering the use of donepezil and cilostazol together, it's essential to monitor patients for increased side effects, particularly those affecting the gastrointestinal system, such as nausea, vomiting, and diarrhea. Donepezil, an acetylcholinesterase inhibitor used for Alzheimer's disease, and cilostazol, a phosphodiesterase inhibitor used for intermittent claudication, both have the potential to cause gastrointestinal side effects.
- The most recent study 1 does not provide information on the interaction between donepezil and cilostazol.
- A study on cilostazol 2 mentions significant drug interactions with CYP3A4 or CYP2C19 inhibitors, but does not specifically mention donepezil.
- A study on donepezil 3 does not mention any interactions with cilostazol. Despite the lack of documented interaction, patients taking this combination should be monitored for increased side effects, particularly gastrointestinal symptoms. If such symptoms occur, dosage adjustments or alternative medications might be necessary. Patients should report any unusual symptoms to their healthcare provider promptly. In many cases, the benefits of using both medications may outweigh the risks, especially when each medication is addressing a distinct medical condition.