From the Research
Pantoprazole has not been definitively linked to hearing loss, but there is a potential association between long-term use of proton pump inhibitors (PPIs) like pantoprazole and an increased risk of hearing impairment. While pantoprazole is generally considered safe and effective for treating conditions like gastroesophageal reflux disease (GERD) and peptic ulcers, patients using it long-term (typically more than a year) should be aware of this possible risk. The standard dose for adults is usually 40 mg once daily, but this can vary based on the condition being treated.
Key Points to Consider
- A study published in 2018 1 found that pantoprazole did not ameliorate cisplatin-associated ototoxicity or nephrotoxicity, suggesting that pantoprazole may not have a direct impact on hearing loss.
- A comprehensive review published in 2020 2 identified 194 systemically administered medications associated with ototoxicity, but did not specifically mention pantoprazole as a potential cause of hearing loss.
- A more recent review published in 2024 3 discussed the latest advances in drug-induced hearing loss, but did not provide any new information on the potential link between pantoprazole and hearing loss.
Clinical Implications
If you're concerned about hearing loss while taking pantoprazole, discuss this with your healthcare provider. They may recommend periodic hearing tests or consider alternative treatments if appropriate. The mechanism behind this potential link is not fully understood, but it may involve changes in the absorption of certain nutrients that are important for ear health. It's essential to note that the benefits of pantoprazole in managing acid-related disorders often outweigh this potential risk for most patients.
Treatment and Prevention
- Patients using pantoprazole long-term should be aware of the potential risk of hearing impairment and discuss this with their healthcare provider.
- Healthcare providers may recommend periodic hearing tests or consider alternative treatments if appropriate.
- The benefits of pantoprazole in managing acid-related disorders often outweigh the potential risk of hearing loss for most patients.