What is the recommended prophylaxis for a puncture wound through a shoe?

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Last updated: June 9, 2025View editorial policy

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From the Guidelines

For a puncture wound through a shoe, tetanus prophylaxis should be considered, especially if the wound is tetanus-prone, as defined by the potential to result in an anaerobic environment or contamination with feces, soil, or saliva 1. When evaluating the need for prophylaxis, it's crucial to consider the nature of the wound and the environment in which it occurred.

  • Tetanus-prone injuries, including puncture wounds, should be evaluated for the need for tetanus prophylaxis, according to the Centers for Disease Control and Prevention (CDC) recommendations 1.
  • The CDC guidelines emphasize the importance of assessing the wound for tetanus risk, particularly in mass-casualty settings, but the principles apply to individual cases as well 1.
  • While the provided study does not specifically address antibiotic prophylaxis for puncture wounds through shoes, clinical practice often includes considering broad-spectrum antibiotics to cover potential pathogens introduced by the shoe, such as Pseudomonas aeruginosa.
  • Cleaning the wound thoroughly with soap and water, irrigating with sterile saline if available, and removing any visible debris are essential steps in managing the wound.
  • Applying an antiseptic solution and covering the wound with a sterile dressing, with daily changes, can help prevent infection.
  • Monitoring for signs of infection, such as increasing pain, redness, swelling, warmth, pus, or fever, is critical, and medical attention should be sought promptly if any of these signs develop.

From the Research

Puncture Wound Through Shoe Prophylaxis

  • The recommended prophylaxis for a puncture wound through a shoe is not explicitly stated in the provided studies, but some studies provide relevant information on the treatment and management of puncture wounds.
  • A study on nail puncture wounds through rubber-soled shoes found that 36 (37.5%) of 96 patients were treated conservatively, while 60 (62.5%) were treated surgically 2.
  • The same study found that treatment success was observed in 91 (94.8%) of the patients, and the median lag time before admission for the less successfully treated group was longer than that for the successfully treated group 2.
  • Another study found that 53 (46.5%) of 114 patients with high-risk feet did not have up-to-date tetanus immunization, and 79.2% of those patients received a tetanus-containing vaccine booster 3.
  • The use of antibiotic prophylaxis is recommended for all clean-contaminated, contaminated, and dirty procedures, and is considered optional for most clean procedures 4.
  • A study on the role of surgical debridement in the treatment of systemic tetanus found that surgical debridement of infected tissue is intended to reduce the number of spores and limit the extent of the disease 5.

Tetanus Prophylaxis

  • Tetanus prophylaxis is an important component of the management of puncture wounds, especially in high-risk patients such as those with diabetes mellitus 3.
  • A study found that guidelines for tetanus prophylaxis among high-risk podiatric medical patients are not followed in all patients, and recommends that physicians take a detailed tetanus immunization history and vaccinate patients if the tetanus history is unclear 3.
  • The use of tetanus-containing vaccine boosters and tetanus immunoglobulins is recommended for patients with high-risk feet who do not have up-to-date tetanus immunization 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Nail puncture wound through a rubber-soled shoe: a retrospective study of 96 adult patients.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 2010

Research

High-Risk Patients with Infected Puncture Wounds and Appropriate Tetanus Prophylaxis.

Journal of the American Podiatric Medical Association, 2023

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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