Can you write a SOAP note for a 47-year-old female at a 1‑month follow‑up for refractory heartburn (previously prescribed pantoprazole and protonix [omeprazole]), with negative Helicobacter pylori test and negative computed tomography of the abdomen and pelvis, now reporting increased fatigue and dry skin, and include perimenopause education, a return visit in 2 weeks, and the appropriate ICD‑10 and CPT codes?

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Last updated: October 6, 2026 • View editorial policy

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SOAP Note: 47-Year-Old Female with Refractory Heartburn

SUBJECTIVE

Chief Complaint: Follow-up for persistent heartburn despite 1 month of PPI therapy

History of Present Illness:

  • 47-year-old female returns for 1-month follow-up of heartburn symptoms
  • Previously prescribed pantoprazole (note: pantoprazole and Protonix are the same medication 1)
  • Reports inadequate symptom control on current therapy
  • Associated symptoms: increased fatigue and skin dryness
  • H. pylori testing: negative
  • CT abdomen/pelvis: negative for structural abnormalities

Review of Systems:

  • GI: Persistent heartburn, no dysphagia, no alarm symptoms
  • Constitutional: Fatigue
  • Integumentary: Dry skin
  • Gynecologic: Perimenopausal symptoms

OBJECTIVE

Vital Signs: [Document as obtained]

Physical Examination:

  • General: Alert, no acute distress
  • Skin: Dry skin noted
  • Abdomen: [Document findings - typically soft, non-tender]
  • Other systems: [Document as examined]

Diagnostic Studies Reviewed:

  • H. pylori test: Negative
  • CT abdomen/pelvis: Negative

ASSESSMENT

Primary Diagnoses:

  1. Gastroesophageal reflux disease (GERD), refractory to initial PPI therapy - ICD-10: K21.9
  2. Perimenopause - ICD-10: N95.8
  3. Fatigue - ICD-10: R53.83
  4. Dry skin - ICD-10: L85.3

Clinical Reasoning:

For refractory heartburn, escalate PPI therapy to twice-daily dosing before pursuing additional diagnostic testing 2. The 2022 AGA guidelines recommend that when typical GERD symptoms inadequately respond to once-daily PPI, the dose should be increased to twice daily before switching agents 2. Since this patient has typical heartburn symptoms without alarm features and negative H. pylori testing, she warrants a trial of optimized acid suppression before proceeding to invasive testing such as endoscopy or pH monitoring 2.

The fatigue and dry skin are consistent with perimenopause in this 47-year-old female and should be addressed separately from the GERD management.

PLAN

1. Refractory GERD Management

Medication Adjustment:

  • Increase pantoprazole to 40 mg twice daily (before breakfast and dinner) 2, 1
  • Continue for 4-8 weeks to assess response
  • Emphasize PPI safety for treatment of GERD 2

Lifestyle Modifications (Patient Education Provided):

  • Elevate head of bed 6-8 inches
  • Avoid meals within 3 hours of bedtime
  • Weight management if applicable
  • Avoid trigger foods (caffeine, alcohol, chocolate, fatty foods, citrus)
  • Diaphragmatic breathing exercises 2

Next Steps if Inadequate Response:

  • If symptoms persist despite twice-daily PPI at 2-week follow-up, will consider:
    • Upper endoscopy to evaluate for erosive esophagitis (Los Angeles classification), hiatal hernia (Hill grade), and Barrett's esophagus 2
    • 24-hour pH-impedance monitoring on PPI therapy if endoscopy negative 2
    • Evaluation for functional heartburn, reflux hypersensitivity, or behavioral disorders 2

2. Perimenopause Management

Patient Education Provided:

  • Discussed normal perimenopausal transition
  • Explained relationship between hormonal changes and symptoms (fatigue, dry skin)
  • Reviewed expected timeline and symptom management strategies

Symptomatic Management:

  • For dry skin: Recommend fragrance-free moisturizers, avoid hot showers
  • For fatigue: Discussed sleep hygiene, regular exercise, stress management
  • Will reassess need for hormone therapy or other interventions at follow-up

3. Follow-Up Plan

  • Return visit in 2 weeks to assess:
    • Response to twice-daily PPI therapy
    • Perimenopausal symptom progression
    • Need for further diagnostic evaluation if GERD symptoms persist

4. Billing Codes

CPT Codes:

  • 99214 - Office visit, established patient, moderate complexity (20-29 minutes of medical decision making)
  • 99401 or 99402 - Preventive medicine counseling (perimenopause education, if time documented separately)

ICD-10 Codes:

  • K21.9 - Gastroesophageal reflux disease without esophagitis
  • N95.8 - Other specified menopausal and perimenopausal disorders
  • R53.83 - Other fatigue
  • L85.3 - Xerosis cutis (dry skin)

Clinical Caveat: Approximately 30% of patients with refractory reflux symptoms do not have GERD but rather functional heartburn or other disorders 3. If this patient fails to respond to optimized PPI therapy, objective testing with endoscopy and pH monitoring is essential before considering escalation to surgical or endoscopic interventions 2.

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